Table 2 Dose escalation schedule
DMXAA dose level (mg m−2) | No. of patients | No. of courses | Patients with DLT |
|---|---|---|---|
6 | 3 | 11 | 0 |
10.2 | 3 | 9 | 0 |
20.4 | 3 | 6 | 0 |
40.8 | 3 | 6 | 0 |
81.6 | 3 | 4 | 0 |
160 | 3 | 6 | 0 |
240 | 3 | 7 | 0 |
360 | 3 | 6 | 0 |
500 | 6 | 19 | 0 |
650 | 3 | 6 | 0 |
850 | 3 | 6 | 0 |
1100 | 3 | 13 | 0 |
1375 | 3 | 9 | 0 |
1650 | 3 | 8 | 0 |
2000 | 3 | 7 | 0 |
2600 | 3 | 10 | 0 |
3100 | 3 | 5 | 0 |
3700 | 7a | 18 | 1 |
4900 | 3a | 5 | 3 |
