Table 8 Meta-analysis of the studies performed in neuroendocrine tumoral lung cancer, with their characteristics

From: Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

Group of neuroendocrine tumoral lung cancer ( n =3)

Study

Method

Threshold

QS (%)

N Pts

Bcl-2+ (%)

HR

95% CI

Brambilla et al (1996)

IHC-clone 124

>50

41

43

56

11.48

1.34–98.01

Eerola et al (1999)

IHC-clone 124

NM

45

20

18

0.44

0.13–1.43

Santinelli et al (1999)

IHC-clone 124

NM

49

23

61

1.81

0.57–5.77

Overall (fixed-effects model)

  

86

55

1.26

0.58–2.72

Overall (random-effects model)

    

1.71

0.35–8.41

χ2 statistic for heterogeneity=6.79, 2 df, P=0.03

  1. The meaning of the symbols is described in Table 3.
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