Table 4a (a): Effect of uPAR suppression on [3H]-collagen IV degradation in HCT116 cell lines

From: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells

 

Matrix degradation (CPM/3 × 105 cells)

Cell type

−Plg

+Plg

HCT116 (mock)

275±32

600±56*

HCT116 (A/S)

264±30

308±22

  1. Matrix degradation of the cells was measured by the release of [3H]-collagen IV in the medium. Results are shown as mean±S.E.M of three different experiments performed in triplicate.
  2. Significantly different, P<0.001, compared to control cells in the absence of Plg.
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