Figure 1
Antitumour activity of radiation therapy (5 Gy TBI) and ONYX-015 in p53 mutant IGRG88 and p53 wildtype IGRG121 subcutaneous malignant glioma xenografts. Mice bearing subcutaneous IGRG88 (A, B) and IGRG121 xenografts (C, D) were randomly assigned to four groups: control animals injected with PBS (open square □), animals irradiated with 5 Gy TBI (open circle ○), animals injected with ONYX-015 108 PFU day−1 × 5 in IGRG88, and 107 PFU day−1 × 5 in IGRG121 (solid square ▪), and animals irradiated with 5 Gy TBI and injected with ONYX-015 108 PFU day−1 × 5 or 107 PFU day−1 × 5, respectively (solid circle •). Panels (A) and (C) give the means of all treatment groups, panels (B) and (D) show the individual tumours of animals subjected to combination treatment compared to the mean of the controls. Each line represents one individual tumour.
