Table 4 Toxicities at or above grade 2 and their time of onset

0101

Asthenia

2

4

Hypercholesterolaemia

2

8

0103

Hypercholesterolaemia^a

4

1

0201

Hypercholesterolaemia

2

8

0105

Asthenia

2

16

Vomiting

2

16

Hypercholesterolaemia

2

1

0206

Asthenia

3

6

Anorexia

2

4

0106

Anorexia

2

4

Abdominal pain

2

4

0107

Abdominal pain

2

4

Asthenia

2

4

0207

Asthenia

2

8

0208

Asthenia

2

8

0108

Anorexia

2

8

Nausea

2

8

Vomiting

2

8

Back pain

2

8

Nil

0111

Nausea^b

2

2

Vomiting^b

2

2

0210

Asthenia

2

2

Back pain

2

2

Hypertriglyceridaemia^a

2

2

Hypercholesterolaemia

3

12

0115

Dry skin

2

4

Cheilitis

2

4

Sore nose

2

4

Stiff joints

2

8

0116

Cheilitis

2

4

Back pain

2

4

Sore nose

2

8

Hypertriglyceridaemia

2

2

0117

Anorexia

2

4

Cheilitis

2

8

0214

Asthenia

3

8

Back pain

3

8

Myalgia

2

12

0112

Hypercalcaemia

3

4

Joint stiffness

2

4

0113

Asthenia

2

4

0114

Cheilitis

2

2

Dry skin

2

2

0211

Headache

2

2

0212

Myalgia

2

2

0213

Hypertriglyceridaemia

4

2