Table 2 Dose modification
Reasons for cessation of irinotecan treatment | ||||||
|---|---|---|---|---|---|---|
Course | No. of patients | On Day 8 | On Day 15 | Dose intensity | ||
First | 50 | Total | 4 | Total | 12 | 90.0 |
Brain infarction | 1 | Brain infarction | 1 | |||
Infection | 1 | Pneumonitis | 1 | |||
Thrombocytopenia | 1 | Diarrhoea | 1 | |||
Diarrhoea | 1 | Leucopenia | 6 | |||
Thrombocytopenia | 2 | |||||
Leucopenia and Thrombocytopenia | 1 | |||||
Second | 49 | Total | 0 | Total | 12 | 89.5 |
1 | Infection | 1 | ||||
Leucopenia | 6 | |||||
Thrombocytopenia | 3 | |||||
Leucopenia and Thrombocytopenia | 1 | |||||
Third | 39 | Total | 1 | Total | 19 | 78.5 |
Leucopenia | Leucopenia | 5 | ||||
Thrombocytopenia | 7 | |||||
Leucopenia and Thrombocytopenia | 7 | |||||
