Table 1 Expression of the MK and AFP genes in human HCC specimens

From: A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the α-fetoprotein promoter

     

Pathology

Expression a

 
     

HCC

Noncancerous

MK

AFP

Serum AFP b

No

Age

Gender

HBs antigen

HCV antibody

  

(HCC/Noncancerous)

 

(ng ml−1)

1

23

M

+

−

mode, trab/pseud

CH

+/−

+/+

21

2

48

M

+

−

mode, sci

CH

+/−

+/−

10 892

3

52

M

+

−

mode, trab

CH

+/−

−/−

70

4

57

M

−

+

mode, trab

CH

+/−

−/−

23

5

61

M

−

+

well, trab

CH

+/−

−/−

15

6

66

M

−

+

poor, com

CH

+/−

−/−

5

7

68

M

−

+

mode, trab

CH

+/−

−/−

3

8

69

M

+

−

mode, trab

CH

+/−

−/−

26

9

73

M

+

−

mode, trab

CH

+/−

−/−

124

10

49

F

+

−

mode, trab

CH

+/−

−/−

3

11

52

F

NA

NA

poor, com

CH

−/−

−/−

41

12

58

F

+

−

mode, trab

CH

+/−

+/−

1434

13

59

F

−

+

well, trab

CH

+/−

−/−

572

14

74

F

−

+

mode, trab

LC

+/−

−/−

2999

15

55

M

−

+

well, trab

LC

+/−

−/−

14

  1. Abbreviations: M=male, F=female, NA=not available, well=well differentiated, mode=moderately differentiated, poor=poorly differentiated, trab=trabecular type, pseu=pseudoglandular type, com=compact type, sci=scirrhous type, CH=chronic hepatitis, LC=liver cirrhosis. aExpression of the MK and AFP genes in HCC and noncancerous region of the same patients was examined with Northern blot analysis and was shown as positive (+) or negative (−). bSerum AFP before surgical operation.
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