Table 2 Response to primary chemotherapy and outcome for all patients (n=39)

From: Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy

First-line chemotherapy

Response

Second-line

chemotherapy

Overall response

Postoperative status

Relapse

Outcome

CV, n=28

14 OR

CV, n=11

None

11 PR

7 CR, 4 VGPR

 

11 CR

  

CE, n=3a

None, n=2

2 PR

2 VGPR

2 local

2 CR

   

CAdO, n=1

1 PR

1 VGPR

 

1 VGPR

 

10 NR

CE, n=10

None, n=6

3 PR

2 CR, 1 VGPR

 

3 CR

    

3 NR

2 CR, 1 VGPR

1 local

3 CR

   

CAdO, n=4

2 PR

1 CR, 1 PR

 

2 CR

    

2 NR

2 CR

 

1 VGPR, 1 PR

 

4 NE

CV, n=3

None

2 PR, 1 NR

3 CR

 

3 CR

  

CE, n=1

None

1 PR

1 CR

 

1 CR

CE, n=10

6 OR

CAdO, n=4

 

4 PR

1 CR, 3 VGPR

 

4 VGPR

  

CV, n=2

 

2 PR

1 CR, 1 VGPR

 

2 CR

 

3 NR

CAdO, n=2

None

1 PR

1 CR

 

1 CR

    

1 NR

1 VGPR

1 local

1 VGPR

  

CE, n=1

CAdO, n=1

1 PR

1 CR

 

1 VGPR

 

1 NE

CAdO, n=1

 

1 PR

1 CR

 

1 CR

Observation, n=1

      

1 CR

  1. CV=cyclophosphamide–vincristine; CE=carboplatin–etoposide; CAdo=cyclophosphamide–doxorubicin–vincristine; CR=complete remission; VGPR=very good partial remission; PR=partial remission; OR=objective response; NR=no response.
  2. aThose three children received CE because persisting neurological symptoms or no intraspinal component shrinkage after CV courses (see text).
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