Table 1 Odds ratios (ORs) and 95% confidence intervals (CIs) for adenocarcinomas and squamous cell carcinomas of the cervix in relation to sexual behaviour and body weight

From: Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case–Control Study of Cervical Cancer

 

Adenocarcinoma

Squamous cell carcinoma

Squamous vs adenocarcinoma

 

Cases/controls

OR a

95% CI

Cases/controls

OR b

95% CI

Squamous/adeno cases

OR c

95% CI

Lifetime number of sexual partners

         

 1

52/417

1.00

 

60/417

1.00

 

60/52

1.00

 

 2–4

84/330

1.96

1.31–2.93

186/330

3.31

2.34–4.70

186/84

1.65

1.00–2.73

 5+

44/176

1.98

1.21–3.26

145/176

4.09

2.75–6.08

145/44

1.78

1.00–3.18

Trend test

  

P=0.1

  

P<0.0001

  

P=0.3

Lifetime number of regular sexual partners (3+ months) a

         

 0 or 1

63/499

1.00

 

91/499

1.00

 

91/63

1.00

 

 2

60/223

1.97

1.29–3.02

111/223

2.30

1.62–3.27

111/60

1.01

0.61–1.67

 3+

57/201

2.18

1.36–3.47

189/201

3.40

2.38–4.86

189/57

1.63

0.97–2.71

Trend

  

P=0.003

  

P<0.0001

  

P=0.03

Lifetime number of nonregular sexual partners b

         

 0

101/603

1.00

 

170/603

1.00

 

170/101

1.00

 

 1–4

66/251

1.26

0.85–1.87

163/251

1.39

1.02–1.89

163/66

1.09

0.70–1.70

 5+

13/69

0.75

0.37–1.52

58/69

1.29

0.80–2.07

58/13

1.28

0.60–2.75

Trend

  

P=0.3

  

P=0.5

  

P=0.5

Age at first intercourse (years)

         

 20+

32/283

1.00

 

42/283

1.00

 

42/32

1.00

 

 18–19

57/297

1.41

0.86–2.32

103/297

1.43

0.93–2.20

103/57

1.03

0.55–1.92

 ⩽17

91/343

2.01

1.23–3.30

246/343

2.70

1.78–4.11

246/91

1.38

0.75–2.55

Trend

  

P=0.004

  

P<0.0001

  

P=0.2

Weight at reference age (kg) c

         

 <55

52/289

1.00

 

141/289

1.00

 

141/52

1.00

 

 55–64

82/359

1.25

0.84–1.86

151/359

0.95

0.70–1.30

151/82

0.71

0.45–1.13

 65+

45/273

1.00

0.63–1.57

99/273

0.85

0.61–1.20

99/45

0.90

0.54–1.52

Trend

  

P=0.7

  

P=0.4

  

P=0.8

Body mass index at reference age c

         

 Normal (20–24.9)

104/540

1.00

 

228/540

1.00

 

228/104

1.00

 

 Overweight/obese (25+)

40/219

0.98

0.64–1.49

78/219

0.87

0.62–1.23

78/40

0.89

0.55–1.46

 Underweight (<20)

35/162

1.16

0.74–1.81

85/162

1.11

0.79–1.55

85/35

0.90

0.54–1.49

  1. ORa, odds ratio for adenocarcinoma vs controls; ORb, odds ratio for squamous cell carcinoma vs controls; ORc, odds ratio for squamous cell carcinoma cases vs adenocarcinoma cases; all adjusted for age, region, smoking, duration of oral contraceptive use, number of negative screening results and education and adjusted as appropriate for total number of sexual partners and age at first intercourse.
  2. aAdjusted for nonregular partners instead of total partners. bAdjusted for regular partners instead of total partners. cReference age=age 1 year before diagnosis (cases) or pseudodiagnosis (controls).
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