Table 4 Treatment details, response, and subsequent course of disease

Patient	Age (years)	Sex	Stage	Number of treated metastases	IL-2 dose (MIU)	Weeks of treatment	Histopathologic response evaluation	Local response	Subsequent course of systemic disease, systemic therapy	Current status
1	38	F	III	3	281	16	Not done	2 CR, 1 NA	VM (4 M)/T+IFN	DE
2	62	F	III	17	397.5	57	Done	17 CR	Stable	AL, DF
3	69	F	III	5	447	53	Done	5 CR	VM (16 M)/IFN	DE
4	61	M	III	4	61	12	Not done	4 PR	VM (3 M)/T+IFN	DE
5	74	M	III	2	99	8	Not done	2 CR	VM (4 M)/T+IFN	AL, DF
6	59	F	III	3	18	2	Not done	3 CR	Stable	AL, DF
7	83	F	III	1	18	4	Not done	1 CR	VM (6 M)	AL
8	65	M	IV	50	79	8	Done	50 CR	VM (2 M)/T+IFN	DE
9	63	M	III	11	287	18	Done	10 CR, 1 NA	VM (5 M)/IFN	AL
10	58	M	III	1	8	5	Done	1 CR	Stable	AL, DF
11	52	F	IV*	3	115	4	Done	3 CR	Further progression/V	DE
12	30	F	III	3	103	7	Not done	3 CR	Further progression/BOLD	DE
13	35	F	IV*	15	119.2	12	Done	15 PR	Further progression/D+IFN	DE
14	68	M	IV	45	91	4	Done	45 CR	Stable	AL, DF
15	60	F	IV*	7	118	20	Not done	4 NA, 3 PD	Further progression/T	AL
16	66	F	III	5	18	2	Not done	5 CR	Stable	AL, DF
17	64	M	III	1	15.5	2	Done	1 CR	Stable	AL, DF
18	51	F	IV*	4	88	8	Not done	1 PR, 3 PD	Further progression/T+IFN	DE
19	64	F	III	2	175	8	Done	1 CR, 1 PD	VM (7 M)/S+HP	AL, DF
20	78	M	III	20	38.5	12	Done	20 CR	VM (2 M)	AL
21	72	F	III	20	10.5	5	Not done	20 CR	Stable	AL, DF
22	19	M	IV*	2	9	1	Not done	2 NA	Further progression/R	DE
23	59	M	IV*	1	54	3	Not done	1 PR	Further progression/T	AL
24	70	F	III	20	67.5	4	Done	20 CR	Stable	AL, LM

Stage: IV^*=visceral metastases; IL-2 dose (MIU): cumulative dose expressed in 10⁶ international units; Response: CR=complete response, PR=partial response, NA=not assessable, PD=progression; Subsequent course of systemic disease: VM (4 M)=progression to stage IV with visceral metastasis (4 months after commencement of IL-2 therapy), D=dacarbazine, IFN=interferon-alfa, T=temozolomide, V=vindesine, BOLD=polychemotherapy (BOLD regimen), S=surgery, HP=hyperthermic limb perfusion, R=radio therapy; Current status (July 2000): Al=alive, DF=disease free, LM=local metastatsis, VM=visceral metastasis, DE=dead.

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