Table 1 List of growth factor and cytokine substrates of MMPs and ADAMs

Metalloproteinase	Growth factor/cytokine targeted (released from)	Reference
MMP-1	IGF (IGFBP2)	Vu and Werb (2000)
	(IGFBP3)	Vu and Werb (2000)
	(IGFBP5)	Vu and Werb (2000)
	FGF (perlecan)	Vu and Werb (2000)
	TNF-α	Gearing et al (1994)
MMP-2	IGF (IGFBP3)	Vu and Werb (2000)
	(IGFBP5)	Vu and Werb (2000)
	IL1-β	Vu and Werb (2000)
	TGF-β (decorin)	Imai et al (1997)
	(LAP)	Yu and Stamenkovic (2000)
	TNF-α	Gearing et al (1994)
MMP-3	HB-EGF	Egeblad and Werb (2002)
	FGF (perlecan)	Vu and Werb (2000)
	IGF (IGFBP3)	Vu and Werb (2000)
	IL1-β	Vu and Werb (2000)
	TGF-β (decorin)	Imai et al (1997)
	TNF-α	Gearing et al (1994)
MMP-7	TGF-β (decorin)	Imai et al (1997)
	TNF-α	Gearing et al (1994)
		Haro et al (2000)
	HB-EGF	Egeblad and Werb (2002)
MMP-9	IGF (IGFBP3)	Vu and Werb (2000)
	IL1-β	Vu and Werb (2000)
	TGF-β (LAP)	Yu and Stamenkovic (2000)
	TNF-α	Gearing et al (1994)
	VEGF (unknown)	Bergers et al (2000)
	sKitL	Heissig et al (2002)
MMP-11	IGF (IGFBP-1)	Manes et al (1997)
MMP-12	TNF-α	Egeblad and Werb (2002)
MMP-14	TNF-α	Egeblad and Werb (2002)
MMP-17	TNF-α	English et al (2000)

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