Figure 7
From: c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis
Role of p21 in the apoptotic response to camptothecin. Targeted inactivation of both alleles of p21Waf1/Cip1 in HCT116 colon cancer cells resulted in significant sensitisation to camptothecin-induced apoptosis. The mean of four different experiments±standard error of the mean is shown. Asterisks indicate significant differences (Student's t-test, P<0.004) between apoptotic levels in HCT116 p21+/+ and −/− for a given dose.
