Figure 8
From: c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis
cDNA microarray analysis of LoVo and isogenic L2 and L3 cells overexpressing c-Myc. (A) The number of genes identified as differentially expressed is a function of the cutoff used. Selection of a stringent cutoff value of four-fold reduces the number of false positives expected when assessing differences in gene expression between LoVo and L2/L3 cells. (B) TreeView image showing the expression profile of the 34 genes with over four-fold expression difference between LoVo and L2/L3 that characterise camptothecin-resistant and -sensitive cells. Both replicas are shown. Red and green indicate genes that are over-represented and under-represented, respectively, relative to the reference RNA used (see Materials and Methods).
