Table 2 Relative risk of lung cancer by aspirin use in the HPFS, 1986–2000

From: Aspirin use and lung cancer in men

 

Aspirin use a

Variable

1986

1986+1988

1986+1988+1990

1986+1988+1990+1992

Follow-up periodb

1986–2000

1988–2000

1990–2000

1992–2000

Total cases

 Nonusers, cases/person-years

204/428 688

96/202 457

66/126 065

22/44 436

 Users, cases/person-years

124/172 765

64/93 431

41/52 730

28/37 478

 Age-adjusted RRc (95% CI)

1.19 (0.95–1.49)

1.11 (0.80–1.53)

1.07 (0.72–1.60)

1.18 (0.66–2.10)

 Multivariate RRd (95% CI)

1.13 (0.89–1.43)

0.98 (0.70–1.36)

0.88 (0.58–1.34)

0.89 (0.47–1.67)

Non-small-cell carcinomas

 Nonusers, cases/person-years

140/428 717

69/202 466

45/126 073

13/44 441

 Users, cases/person-years

87/172 789

49/93 441

33/52 733

24/37 479

 Age-adjusted RRc (95% CI)

1.25 (0.95–1.64)

1.20 (0.82–1.74)

1.27 (0.80–2.01)

1.76 (0.88–3.54)

 Multivariate RRd (95% CI)

1.16 (0.88–1.54)

1.02 (0.69–1.49)

0.98 (0.61–1.58)

1.10 (0.52–2.35)

  1. aAspirin use was defined as aspirin use two or more times per week. Users consistently reported regular aspirin use (1986; 1986 and 1988; 1986, 1988, and 1990; 1986, 1988, 1990, and 1992); nonusers consistently reported no aspirin use during the specified time periods.
  2. bSeparate proportional hazards models were analysed for each of the four follow-up periods.
  3. cProportional hazards models adjusted for current age.
  4. dProportional hazards model adjusted for current age, age at started to smoke regularly, and smoking status (includes dose and time since quitting).
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