Figure 5
Effect of α-MSH on melanoma invasion through human fibronectin. The invasion assay was run for (A) 20 h with HBL melanoma cells, (B) 52 h with A375-SM cells, (C) 15 h with C8161 cells and (D) 15 h with untransfected and stably transfected (with MC-1R) C8161 cells. Values shown represent the raw data (% mean invasion) obtained for each experiment, which were normalised by relating all values to the control level of invasion in each individual experiment (taken as 100%). Statistical comparison is made between invasion in the absence (control) and presence of α-MSH. *P<0.05, **P<0.01, ***P<0.001.
