Figure 6

Melanoma cell invasion through reconstructed skin. Morphology (A–C) of composites and the extent of HBL invasion (D) through reconstructed skin±α-MSH/IBMX. In (A) composites contain keratinocytes (K) and fibroblast (F) cells; in (B) composites contain keratinocytes, fibroblasts and HBL melanoma cells, and in (C) composites contain keratinocytes, fibroblasts, HBL melanoma cells and α-MSH/IBMX. Statistical comparison in (D) is made between HBL cell invasion in the absence (control) and presence of α-MSH/IBMX. ***P<0.001.