Figure 2
Tissue accumulation of vincristine. Mice receiving 1 mg kg−1 were killed at 1 and 4 h after drug administration. Drug levels were determined by HPLC. Each bar represents at least four animals and the error bar depicts the s.e. Statistical analyses were performed by ANOVA using Bonferroni post hoc test for multiple comparisons. * P<0.05 relative to wild-type; ** P<0.05 relative to Mdr1ab DKO, otherwise not significant.
