Figure 3
In vivo bone marrow toxicity induced by vincristine: effects on WBC. Lethally irradiated wild-type mice, which had received donor marrow from wild-type (n=38), Mrp1 KO (n=33), Mdr1ab DKO (N=18) and Mdr1ab/Mrp1 TKO (n=38) mice, were challenged with 2 mg kg−1 of vincristine administered by i.v. injection (upper panel). The course of the WBC in blood is depicted as percentage of the initial value at day 0 (arbitrarily set at 100%). * P<0.05 relative to wild type, otherwise not significant. The lower panel depicts the results in Mdr1ab/Mrp1 TKO donor marrow grafted mice receiving 0.5 mg (n=15), 1 mg (n=20) or 2 mg (n=21) of vincristine per kilogram and show the dose-dependent response on WBC.
