Figure 4 | British Journal of Cancer

Figure 4

From: P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo

Figure 4

In vivo bone marrow toxicity induced by vincristine: effects on Hb levels. Lethally irradiated wild-type mice received donor marrow from wild-type, Mrp1 KO, Mdr1ab DKO and Mdr1ab/Mrp1 (TKO) mice were challenged by i.v. administration of 2 mg of vincristine per kilogram (left panel). The course of the haemoglobin concentration is depicted as percentage of the initial value at day 0 (arbitrarily set at 100%). * P<0.05 relative to wild type; otherwise not significant.

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