Table 1 Toxicity of bone marrow progenitor cells (in vitro)

From: P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo

Conc. (ng ml−1)

Wild type

Mrp1 KO

Mdr1ab DKO

Mdr1ab/Mrp1 TKO

100

−

−

−

−

50

+

−

−

−

25

+

−

+

−

10

+

±

+

−

5

ND

+

ND

−

2

ND

+

ND

±

1

ND

+

ND

+

  1. Bone marrow cells harvested from wild-type, Mrp1 KO, Mdr1ab DKO and Mdr1ab/Mrp1 (TKO) mice were incubated continuously with various concentrations of vincristine. Colonies were scored by day 5. Wells were scored with − when the number of colonies was reduced by more than 90% relative to control wells without the drug (IC90). ± indicates a borderline value, whereas clearly less than 90% reduction is marked by a + sign. ND means not determined.
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