Table 2 Toxicity of vincristine in mice

From: P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo

    

Decrease in body weight

 
 

Dose (mg kg−1)

Number of animals

Toxic deaths

Median (%)

Range

Day of nadir

Mdr1ab/Mrp1 TKO

0.125

9

0

1.9

0–7.9

2

 

0.25

13

0

3.0

0–7.4

3

 

0.5

9

0

10.3

4.1–19.1

4

 

1

4

2

20.5

14.1–27.2

3–4

Wild ype

1

5

0

4.6

3.6–7.6

2

 

2

5

1

12.1

10.9–20.6

2

 

4

5

5

23.1

21.0–25.1

4

  1. Animals received vincristine by i.v. injection. Body weight was determined daily. Animals experiencing more than 20% body weight loss were killed and counted as toxic deaths. The size of, especially, the highest dose groups was kept as low as possible in order to minimise the number of animals experiencing major discomfort.
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