Table 2 XPD Asp312Asn and Lys751Gln polymorphisms and risk of cutaneous malignant melanoma in the overall analysis and by age, presence of dysplastic naevi or tanning ability
XPD 312 | XPD 751 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Genotype | Case | Control | ORa | (95% CI)a | Genotype | Case | Control | ORa | (95% CI)a | |
Overall analysis | ||||||||||
Asp/Asp (G/G) | 52 | 59 | 1.0 | Ref. 1.5 | Lys/Lys (A/A) | 58 | 59 | 1.0 | Ref. (0.8–2.1) | |
Asp/Asn (G/A) Asn/Asn (A/A) | 112 | 113 | (0.9-2.5) | Lys/Gln (A/C) Gln/Gln (C/C) | 118 | 118 | 1.3 | |||
By age (years) | ||||||||||
17–49 | Asp/Asp (G/G) | 31 | 28 | 1.0 | Ref. (0.4-1.5) | Lys/Lys (A/A) | 34 | 30 | 1.0 | Ref. (0.4–1.5) |
17–49 | Asp/Asn (G/A) Asn/Asn (A/A) | 49 | 74 | 0.7 | Lys/Gln (A/C) Gln/Gln (C/C) | 51 | 75 | 0.7 | ||
50–77 | Asp/Asp (G/G) | 21 | 31 | 1.0 | Ref. (1.6–7.3) | Lys/Lys (A/A) | 24 | 29 | 1.0 | Ref. (1.1–4.9) |
50–77 | Asp/Asn (G/A) Asn/Asn (A/A) | 63 | 39 | 3.4 | Lys/Gln (A/C) Gln/Gln (C/C) | 67 | 43 | 2.3 | ||
Test of heterogeneity of ORsb | P=0.004 | P=0.03 | ||||||||
By presence of dysplastic navi c | ||||||||||
No | Asp/Asp (G/G) | 12 | 29 | 1.0 | Ref. (0.6-3.2) | Lys/Lys (A/A) | 9 | 33 | 1.0 | Ref. (1.1–6.4) |
No | Asp/Asn (G/A) Asn/Asn (A/A) | 40 | 74 | 1.4 | Lys/Gln (A/C) Gln/Gln (C/C) | 46 | 72 | 2.6 | ||
Yes | Asp/Asp (G/G) | 23 | 11 | 1.0 | Ref. (0.3–2.4) | Lys/Lys (A/A) | 26 | 10 | 1.0 | Ref. (0.2–1.6) |
Yes | Asp/Asn (G/A) Asn/Asn (A/A) | 32 | 17 | 0.9 | Lys/Gln (A/C) Gln/Gln (C/C) | 33 | 19 | 0.6 | ||
Test of heterogeneity of ORsb | P=0.52 | P=0.03 | ||||||||
By tanning ability | ||||||||||
High/medium | Asp/Asp (G/G) | 36 | 51 | 1.0 | Ref. (0.7–2.4) | Lys/Lys (A/A) | 41 | 47 | 1.0 | Ref. (0.6–1.8) |
High/medium | Asp/Asn (G/A) Asn/Asn (A/A) | 67 | 92 | 1.3 | Lys/Gln (A/C) Gln/Gln (C/C) | 70 | 99 | 1.0 | ||
Low | Asp/Asp (G/G) | 15 | 8 | 1.0 | Ref. (0.7-7.0) | Lys/Lys (A/A) | 16 | 11 | 1.0 | Ref. (1.0-8.8) |
Low | Asp/Asn (G/A) Asn/Asn (A/A) | 41 | 17 | 2.3 | Lys/Gln (A/C) Gln/Gln (C/C) | 44 | 15 | 3.0 | ||
Test of heterogeneity of ORsb | P=0.39 | P=0.08 | ||||||||
