Figure 1

Examples of immunohistochemical staining of the cell cycle regulatory proteins in different DCIS tumours: (A) cyclin D1 low; (B) cyclin D1 high. (Note that the intensity of the cytoplasmic staining only differs slightly between (A) and (B), in contrast to the nuclear staining.); (C) cyclin E low; (D) cyclin E high; (E) p16 low; (F) p16 high; (G) p27 low; (H) p27 high.