Table 4 Stage 2 grade of haematological toxicity

From: A phase I (tumour site-specific) study of carboplatin and temozolomide in patients with advanced melanoma

 

0

1

2

3

4

 

Cycles (patients)

Carboplatin AUC 3

Anaemia

2 (1)

10 (3)

2 (2)

0 (0)

0 (0)

Thrombocytopenia

7 (3)

2 (1)

5 (2)

0 (0)

0 (0)

Neutropenia

11 (3)

3 (2)

0 (0)

0 (0)

0 (0)

Carboplatin AUC 4

 Anaemia

20 (9)

6 (4)

3 (3)

2 (1)

1 (1)

 Thrombocytopenia

13 (4)

0 (0)

0 (0)

3 (2)

16 (6)

 Neutropenia

17 (5)

2 (2)

7 (2)

3 (2)

3 (2)

Carboplatin AUC 5

 Anaemia

4 (3)

1 (1)

1 (1)

1 (1)

0 (0)

 Thrombocytopenia

2 (1)

0 (0)

0 (0)

3 (2)

2 (1)

 Neutropenia

3 (2)

1 (1)

0 (0)

2 (2)

1 (1)

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