Table 3 Correlation of immunohistochemistry and mutations in each lesion

From: TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva

Lesion

IHC+/mt+

IHC−/mt+

IHC+/mt−

IHC−/mt−

SCC

66.7% (14/21)

33.3% (7/21)

83% (5/6)*

16.7% (1/6)

SH

50% (1/2)

50% (1/2)**

14.3% (1/7)

85.7% (6/7)

LS

42.8% (3/7)

57% (4/7)

37.5% (3/8)

62.5% (5/8)

  1. *Mutation in intron considered wild-type TP53.
  2. **Polymorphism considered wild-type TP53.
  3. IHC=immounohistochemistry; mt=mutation; SCC=squamous cell carcinoma of the vulva; SH=squamous hyperplasia; LS=lichen sclerosus.
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