Figure 2
From: The CHEK2*1100delC mutation has no major contribution in oesophageal carcinogenesis
D22S275 polymorphic marker analysis in samples with CHEK2*1100delC. (A), the allele (arrow), known to be present in all carriers of CHEK2*1100delC (18), is present in all samples with the CHEK2*1100delC mutation (T1–T3 mutated adenocarcinoma samples, T4 mutated squamous cell carcinoma, D1 mutated dysplastic tissue, M1–M3 mutated metaplastic tissue), ‘+C’ represents a control individual with CHEK2*1100delC. (B, C), LOH patterns from two mutated tumours (T1 adenocarcinoma and T4 squamous cell carcinoma) compared with the corresponding normal tissues (N1 and N4) are shown. The arrowhead points to the deleted allele in T4.
