Figure 2

Mean tumour load (±s.d.) estimated for groups of treated (n=5–7) and untreated rats (n=11) at 40 days after inoculation with CC531 cells. Control rats received no surgical treatment or drugs; −CP perf=90 min perfusion at 37°C with 200 ml Dianeal perfusate only; +CP perf/37=90 min perfusion at 37°C with cisplatin in 200 ml Dianeal (8 μg ml⁻¹); +CP perf/40=90 min perfusion at 40°C with cisplatin in 200 ml Dianeal (8 μg ml⁻¹); saline i.p.=bolus injection of 20 ml saline (i.p.); +CP i.p.=bolus injection of cisplatin (4 mg kg⁻¹) in 20 ml saline (i.p.). Tumour load for cisplatin bolus injection was significantly lower than for i.p. saline controls (^*).