Table 5 Nuclear/cytoplasmic localisation of c-Myc comparing normal and invasive cells

From: Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses

Normal cells (frequency percent)

Invasive cells (frequency percent)

Total

(A) Nuclear localisation

  
 

−

+

 

−

28

4

32

+

14

8

22

Total

42

12

54

(B) Cytoplasmic localisation

−

12

13

25

+

9

20

21

Total

21

33

54

  1. In all, 54 pairs (normal vs invasive) of tissues were analysed to answer the questions of (1) whether positivity of nuclear cells in normal tissues is different from that in invasive cells, and similarly (2) whether positivity of cytoplasmic cells in normal tissues is different from that in invasive cells. The data are summarised in the above contingency tables. In all, 22 normal cell specimens were positive for c-Myc staining (40.71%), compared to 12 specimens (22.2%) in invasive cells. The difference is statistically significant (P=0.01) by McNemar's χ2 test (two-sided).
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