Table 4 Pattern of protein nitration in renal tumours: correlation with the nitration of red blood cells and the degree of the inflammatory infiltrate

From: Loss of NOS1 expression in high-grade renal cell carcinoma associated with a shift of NO signalling

 

3-Nitrotyrosine immunohistochemistry

 

Tumour type

Tumour cells

Red blood cells

Inflammatory infiltrate

Oncocytoma

Homogeneous

−

−

Chromophobe RCC

Heterogeneous

+

+

Clear cell RCC

   

 Fürhman I

Heterogeneous

+

++

 Fürhman II

Heterogeneous

+

+++

 Fürhman III

Heterogeneous

+

+++

 Fürhman IV

Heterogeneous

+

+++

  1. 3-Nitrotyrosine immunohistochemistry was performed on paraffin sections of three cases of each tumour type. The immunostaining of tumour cells was referred to as ‘homogeneous’ when a majority of cells was stained with the same intensity and as ‘heterogeneous’ when some parts of the tumour were stained and others devoid of any staining. Immunostaining of red blood cells: (−) denotes absent and (+) denotes majority of red blood cells stained. Semiquantitative evaluation of the inflammatory infiltrate: (−) means absence of infiltrate; (+) denotes a mild infiltrate, (++) a moderate infiltrate and (+++) an abundant infiltrate.
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