Table 6 Urinary excretion of CPT and creatinine clearance
Urinary excretiona (% of the dose) | Creatinine clearanceb (before treatment, ml min−1) | |
|---|---|---|
Cohort 1 (80 mg m−2) | ||
Patient 1 | 34.1 | 60.1 |
Patient 2 | 56.2 | 90.3 |
Patient 3 | 91.8 | 78.2 |
Patient 7 | 60.3 | 48.5 |
Patient 8 | 52.6 | 69.3 |
Patient 9 | 55.4 | 45.1 |
Mean±s.d. | 58.4±18.8 | 65.3±17.5 |
Cohort 2 (120 mg m−2) | ||
Patient 4 | 26.4 | 82.8 |
Patient 5 | 38.4 | 93.7 |
Patient 6 | 40.5 | 76.9 |
Mean±s.d. | 35.1±7.6 | 84.5±8.5 |
