Table 4 Results of Cox proportional hazard model within the first year of follow-up for the whole population

From: CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: results of a meta-analysis in 2063 patients

 

Age

CYFRA 21-1

Stage grouping

PS

Centre

HR

95 CI

P

HR

95 CI

P

HR

95 CI

P

HR

95 CI

P

Montpellier

1.22

(0.99–1.50)

0.047

1.69

(1.37–2.09)

<10−4

1.59

(1.32–1.91)

<10−4

1.87

(1.52–2.31)

<10−4

Heidelberg

1.30

(0.87–1.94)

0.1

1.91

(1.26–2.90)

<10−4

1.34

(1.00–1.80)

0.05

1.44

(0.96–2.15)

0.07

Marseille

0.88

(0.61–1.27)

NS

2.22

(1.54–3.23)

<10−4

1.40

(1.00–1.94)

0.04

2.77

(1.74–4.42)

<10−4

Cuneo

0.79

(0.41–1.52)

NS

1.52

(0.84–2.74)

NS

1.22

(0.82–1.81)

NS

2.27

(1.25–4.14)

6 × 10−3

Bruxelles

1.56

(0.95–2.56)

0.07

1.93

(1.19–3.13)

6 × 10−3

1.63

(0.83–3.18)

NS

2.36

(1.25–4.43)

3 × 10−3

Strasbourg

1.11

(0.60–2.05)

NS

2.20

(1.07–4.52)

0.028

1.56

(0.89–2.76)

NS

3.23

(1.77–5.91)

<10−4

Grenoble

2.70

(1.56–4.67)

2 × 10−4

2.04

(1.18–3.52)

9 × 10−3

1.4

(1.00–1.97)

0.04

1.61

(0.93–2.81)

0.08

Warsaw

0.93

(0.53–1.65)

NS

1.72

(1.03–2.88)

0.034

1.72

(1.04–2.85)

0.03

1.38

(0.79–2.38)

NS

Paris

2.80

(0.97–7.92)

0.05

4.61

(1.64–12.7)

3 × 10−3

3.13

(1.46–6.69)

3 × 10−3

1.74

(0.61–4.96)

NS

Overall

1.26

(1.11–1.44)

4 × 10−4

1.88

(1.64–2.15)

<10−4

1.41

(1.28–1.56)

<10−4

2.01

(1.76–2.30)

<10−4

  1. Codage of variables: all codages were binary except for stage grouping.
  2. Age: median age according to calculation in each centre. HR calculated in patients’ aged more than median age.
  3. CYFRA 21-1: HR affecting patients with a pretreatment serum CYFRA 21-1 level >3.6 ng ml−1.
  4. Performance status according to Zubrod ECOG system. HR affecting patients with a PS 2.
  5. Stage grouping according to the Mountain classification. This variable has been tested according to three modalities: Ia–IIb, IIIa–IIIb, and IV.
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