Figure 4
From: Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation
Effect of estramustine on mitoxantrone drug accumulation in GLC4 and GLC4-MITO. In total, 0, 10 and 25 μ M estramustine were added together with 3 μ M mitoxantrone to 1 × 106 GLC4 and GLC4-MITO cells. Median fluorescence intensity was measured indicating the relative amount of mitoxantrone accumulation. Values represent the median mitoxantrone fluorescence relative to GLC4 with 3 μ M mitoxantrone. Values represent the means of three experiments±s.d. No significant difference was observed in GLC4 with or without estramustine.
