Table 1 Chemosensitivit y of control transfected NCI H460 cells or NCI H460-Akt1 cells

From: Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells

 

NCI H460

Compound

IC50 (μ M) (Control)

IC50 (μ M) (Akt1)

Resistance factor

5-FU

0.03

0.09

3

Cisplatin

0.6

5.6

9.3

Doxorubicin

0.055

0.78

14

Paclitaxel

0.002

0.005

2.5

Mitoxantrone

0.005

0.1

20

  1. Values were determined as average from at least three independent experiments performed as quadruplicates. The resistance factor was calculated as the IC50 value of NCI H460-Akt1 cells divided by the IC50 value of control transfected NCI H460 cells.
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