Figure 6 | British Journal of Cancer

Figure 6

From: Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)

Figure 6

Anti-CP antibody formation in mice after 50 μg MFECPHis (A), MFEdmCPHis (B) and A5CP (C) i.p. every 14 days for four doses. Individual bars represent mice with measurable anti-CP antibodies in each group of eight mice. Comparison of the number of injections prior to a measurable anti-CP antibody response showed no statistically significant difference between groups injected with MFECPHis and MFEdmCPHis (P=0.203; Fisher's exact test), while comparison of the groups immunised with A5CP and MFECPHis showed a statistical trend indicating that injections could be repeated more frequently after MFECPHis compared to A5CP (P=0.077; Fisher's exact test).

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