Table 3 Mutation patterns of APC and p53 genes in PG and NPG carcinomas

From: Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth

 

PG carcinoma

NPG carcinoma

P-value

APC mutation

 Type

29 (100%)

5 (100%)

 

Nonsense

9 (31%)

4 (80%)

0.0189

Missense

1 (3%)

1 (20%)

 

Frameshift

19 (66%)

0 (0%)

 

p53 Mutation

 Type

49 (100%)*

12 (100%)

 

Nonsense

5 (10%)

3 (25%)

0.1805

Missense

35 (71%)

5 (42%)

 

Frameshift

6 (12%)

4 (32%)

 

Splice site

2 (4%)

—

 

Silent

1 (2%)

—

 

 Hot-spot mutation

   

Presence

18 (37%)

0 (0%)

0.0124

Absence

31 (63%)

12 (100%)

 

MSI

 Degree

14 (100%)

3 (100%)

 

MSI-H

7 (50%)

1 (33%)

0.8808

MSI-L

7 (50%)

2 (67%)

 
  1. PG = polypoid growth type; NPG = nonpolypoid growth type; MSI = microsatellite instability; MSI-H = high instability (two or more out of five loci); MSI-L = low instability (one out of five loci);
  2. *= 49 mutations in 48 PG carcinomas (one case having two mutations, one nonsense, and one frameshift).
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