Table 5 c-erbB-2 mRNA expression and regression in SCCa (sensitivity and specificity of response prediction)

From: Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer

 

Regression grading

 

c-erbB-2b

Grades I/II (MiHRc)

Grades III/IV (MaHRd)

Total: n (%)

⩽1 or ⩽1.06e: n (%)

8 (34.8%)

9 (39.1%)

17 (73.9%)

>1 or >1.06e: n (%)

6 (26.1%)

∅

6 (26.1%)

Total: n (%)

14 (60.9%)

9 (39.1%)

23 (100%)

  1. Squamous cell cancer.
  2. bDichotomised c-erbB-2 mRNA levels.
  3. cMinor histopathologic response.
  4. dMajor histopathologic response.
  5. eAll values remain identical if maximum cutoff at 1.06 was chosen from ROC curves. χ2-analysis (Fisher's exact test): P=0.048.
  6. Prediction of MiHR (c-erbB-2 >1): sensitivity 42.8%, specificity: 100%.
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