Table 6 c-erbB-2 mRNA expression and regression in ACa (sensitivity and specificity of response prediction)

From: Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer

 

Regression grading

 

c-erbB-2b

Grades I/II (MiHRc)

Grades III/IV (MaHRd)

Total: n (%)

⩽1 or ⩽1.06e: n (%)

6 (46.2%)

3 (23.1%)

9 (69.2%)

>1 or >1.06e: n (%)

4 (30.8%)

∅

4 (30.8%)

Total: n (%)

10 (76.9%)

3 (23.1%)

13 (100%)

  1. Adenocarcinoma.
  2. bDichotomised c-erbB-2 mRNA levels.
  3. cMinor histopathologic response.
  4. dMajor histopathologic response.
  5. eAll values remain identical if maximum cutoff at 1.06 was chosen from ROC curves. χ2-analysis (Fisher's exact test): not possible (three cells with expected frequencies <5).
  6. Prediction of MiHR (c-erbB-2 >1): sensitivity 40%, specificity: 100%.
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