Table 2 Toxicity of the oxaliplatin-HDFL regimen
Patients (n=55) | Cycles (n=323) | |||
|---|---|---|---|---|
Grade | Grade | Grade | Grade | |
Toxicity | 1–2 | 3–4 | 1–2 | 3–4 |
Haematological | ||||
Neutropenia | 72.7a | 21.8 | 34.3b | 7.1 |
Leukopenia | 58.1 | 7.2 | 21.0 | 1.8 |
Thrombocytopenia | 60.0 | 12.7 | 24.5 | 5.0 |
Febrile neutropenia | 1.8 | 5.4 | 0.3 | 0.9 |
Anaemia | 61.8 | 9.0 | 34.7 | 2.8 |
Gastrointestinal | ||||
Nausea | 81.8 | 10.9 | 38.4 | 2.5 |
Vomiting | 87.2 | 12.7 | 31.6 | 2.2 |
Diarrhoea | 69.1 | 12.7 | 22.0 | 2.4 |
Stomatitis | 50.9 | 3.6 | 13.3 | 0.9 |
Anorexia | 70.9 | 1.8 | 36.5 | 0.3 |
Weight loss | 9.1 | 0 | 1.85 | 0 |
Neuropathic | 72.7 | 12.7 | 46.8 | 2.2 |
Others | ||||
Cardiac | 0 | 1.8 | 0 | 0.3 |
Fever | 27.3 | 1.8 | 7.1 | 0.3 |
Infection without neutropenia | 16.4 | 0 | 4.3 | 0 |
Alopecia | 21.8 | 0 | 16.4 | 0 |
