Table 3 Inhibition of tumour growth by GW654652, a VEGFR kinase inhibitor

From: Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models

 

% Inhibitiona

 
 

10 mg kg−1

30 mg kg−1

100 mg kg−1

ED50(mg kg−1 day−1)

HT29

5

69

98

20±8

HCT116

18

59

71

21±8

HN5

24

46

83

28±10

SW620

12

44

74

46±11

PC3

NDb

21

48

108±50

A375P

NDb

14

49

114±54

  1. a% Inhibition of tumour growth compared to vehicle-treated animals.
  2. bNot detectable.
  3. VEGFR=vascular endothelial growth factor receptor.
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