Table 3 Uveal melanoma – metastases

From: Loss of nonclassical MHC molecules MIC-A/B expression during progression of uveal melanoma

  

MIC-A/Bb

NKG 2-Dc

CD57c

CD3c

No.

TILa

Frequency

Intensity

Frequency

Intensity

Frequency

Frequency

2616/99

(+)

 

 

+

2854/99d

(+)

 

 

(+)

4430/99

+

+e

++

++

+

+

++

800/98

(+)

 

 

+

+

8202/97

(+)

 

 

(+)

9057/97

(+)

 

 

+

++

9059/97

(+)

 

 

+

+

1709/94

++

 

 

3713/95

(+)

 

 

+

6830/95

(+)

 

 

(+)

+

7602/95

(+)

 

 

(+)

5368/92

+

 

 

(+)

  1. aThe inflammatory infiltrate is classified according to the criteria of Elder and Clark as ++: brisk; +: nonbrisk; (+): dim; Ø: absent.
  2. bExpression on melanoma cells.
  3. cExpression on tumour infiltrating lymphocytes.
  4. d#2854/99 and 4430/99 were obtained from the same patient prior or after therapy with fotemustine.
  5. e−: none, (+): single, +: <40%, ++: <80% positive cells.