Figure 2 | British Journal of Cancer

Figure 2

From: Targeting the p53–MDM2 interaction to treat cancer

Figure 2

Nutlins bind MDM2 at the p53-binding pocket. Surface representation of MDM2–Nutlin-2 interaction. The p53 binding area within 6 Å distance from Nutlin-2 is depicted in yellow and Nutlin-2 in green. Nutlin-2 is rotated out of the p53-binding pocket in the lower panel. Coordinates are derived from the crystal structure of MDM2–Nutlin-2 complex (Vassilev et al, 2004).

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