Figure 2
Effect of time on DMF diet on NQO1 activity in human tumour xenografts and normal tissues in CD-1 nude mice. CD-1 nude mice were implanted subcutaneously in the right flank with HCT116 cells and the mice received diet containing 0.3% DMF for 0, 3, 7 or 14 days. The mice were killed, the organs (kidney, liver, lung, heart, forestomach) and the HCT116 xenografts were removed and marrow was obtained. For each tissue, NQO1 activity was measured and is reported as the NQO1 activity in that tissue as a percent of NQO1 activity in the same tissue in mice fed diet containing no DMF. The points represent the means of values obtained from three mice.
