Table 2 Irinotecan dose escalation
Irinotecan cycles (n) | Dose reduction (n) | Dose delay (n) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Dose of irinotecan (mg m−2) | No. of patients | Total | Median (range) | Patients | Cycles | Patients | Cycles | Median dose intensity up to eight cycles (%) | Median dose intensity up to 16 cycles and >8 cycles (%) |
50 | 3 | 39 | 13 (10–15) | 0 | 0 | 2 | 5 | 100 | 74.9 |
75 | 6 | 110 | 18 (7–24) | 0 | 0 | 4 | 13 | 79.4 | 76.7 |
100 | 5 | 106 | 21 (16–24) | 3 | 46 | 5 | 17 | 68.7 | 66.0 |
85 | 8 | 142 | 18 (4–24) | 0 | 0 | 5 | 17 | 88.9 | 84.2 |
Total/overall | 22 | 397 | 3 | 46 | 16 | 52 | 87.5 | 76.3 | |
