Table 3 Toxicity: worst WHO grade per patient across all cycles (n=46)

From: Phase II study of a triplet regimen in advanced colorectal cancer using methotrexate, oxaliplatin and 5-fluorouracil

 

MTX → l-OHP−FU toxicity grade (%)

CI FU+6-S-LV toxicity grade (%)

Toxicity

I

II

III

IV

I

II

III

IV

Mucositis

15

9

9

2

19

11

2

0

Diarrhoaea

13

4

7

0

11

6

2

0

Nausea/vomiting

32

11

9

0

28

9

0

0

Neurotoxicity

43

10

0

0

0

0

0

0

Conjunctivitis

15

0

0

0

17

2

0

0

Hand–foot syndrome

4

2

0

0

30

4

0

0

Haematological

28

9

0

4

28

19

6

0

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