Figure 1
From: Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
Histology of tumours and abnormal intestinal mucosa in Fhit-deficient mice. (A) Gastrointestinal stromal tumour in a female Fhit (−/−) mouse at 20 months of age. Inset, immunostaining with an anti-c-Kit antibody. (B) Leydig cell tumour in a male Fhit (+/−) mouse at 15 months. (C) Dissection micrograph of a duodenal polyp in a Fhit (−/−) mouse at 15 months. (D) Schematic distribution of the small intestinal polyps. Asterisks indicate relative locations of the polyps. (E, F) Immunostaining for β-catenin in polyps of a Fhit (+/−) mouse at 12 months, and Fhit (−/−) at 15 months, respectively. Note the nuclear accumulation of β-catenin (white arrowheads) in (E) and basolateral staining (asterisks) in (F). (G, J) Dissection micrographs of swollen crypts (ileum) in a Fhit (+/−) mouse at 20 months, and fused villi (duodenum) in a Fhit (+/−) at 20 months, respectively. (H, K) Normal ileal mucosa adjacent to the lesions shown in (I, L), respectively. (I, L) Histological sections of ileal swollen crypts in a Fhit (+/−) mouse at 20 months, and fused villi in a Fhit (+/−) at 20 months, respectively. Bars in: (A) 500 μm; (B) 100 μm; (C) 250 μm; (E, F) 50 μm; (G, J) 250 μm; (H, I, K, L) 200 μm.
