Table 1 The correlationship between clinicopathological characteristics and TIMP-3 expression
From: An immunohistochemical study of TIMP-3 expression in oesophageal squamous cell carcinoma
TOMP-3 preserve | TOMP-3 moderate | TOMP-3 reduce | |||
|---|---|---|---|---|---|
Parameters | Total | (n=30) | (n=27) | (n=33) | P–value |
Age (mean±s.d., years) | 60.9±8.3 | 60.9±7.5 | 59.9±8.2 | 61.8±9.1 | NS |
Gender | |||||
Male | 76 | 23 | 23 | 30 | |
Female | 14 | 7 | 4 | 3 | 0.295 |
Differentiation | |||||
Well | 22 | 7 | 6 | 9 | |
Moderate | 45 | 15 | 15 | 15 | |
Poor | 23 | 8 | 6 | 9 | 0.957 |
Location | |||||
Upper | 12 | 1 | 6 | 5 | |
Mid-thora | 55 | 21 | 18 | 16 | |
Lower | 23 | 8 | 3 | 12 | 0.060 |
TNM clinical classification | |||||
T | |||||
T1 | 34 | 20 | 9 | 5 | |
T2 | 13 | 2 | 6 | 5 | |
T3 | 37 | 8 | 11 | 18 | |
T4 | 6 | 0 | 1 | 5 | 0.001 |
N | |||||
N0 | 36 | 16 | 11 | 9 | |
N1 | 54 | 14 | 16 | 24 | 0.108 |
M | |||||
M0 | 74 | 28 | 21 | 25 | |
M1 | 16 | 2 | 6 | 8 | 0.147 |
Stage | |||||
I | 23 | 15 | 4 | 4 | |
II | 28 | 7 | 12 | 9 | |
III | 23 | 6 | 5 | 12 | |
IV | 16 | 2 | 6 | 8 | 0.005 |
No. of lymph node metastases (mean±s.d.) | — | 1.3±1.8 | 3.1±5.9 | 2.5±3.4 | 0.003 |
Lymphatic invasion | |||||
ly (−) | 28 | 13 | 7 | 8 | |
ly (+) | 62 | 17 | 20 | 25 | 0.206 |
Blood vessel invasion | |||||
v (–) | 49 | 18 | 14 | 17 | 0.756 |
v (+) | 41 | 12 | 13 | 16 | |
Infiltrative growth pattern | |||||
inf α | 22 | 14 | 2 | 6 | |
inf β | 60 | 12 | 23 | 25 | |
inf γ | 8 | 4 | 2 | 2 | 0.003 |
Intraepithelial spread | |||||
ie (−) | 45 | 14 | 10 | 21 | |
ie (+) | 45 | 16 | 17 | 12 | 0.111 |
Intramural metastasis | |||||
IM0 | 80 | 27 | 25 | 28 | |
IM1 | 10 | 3 | 2 | 5 | 0.619 |
