Table 1 Characteristics of the study population
From: BRCA1 mutations in ovarian cancer and borderline tumours in Norway: a nested case–control study
Ovarian cancer | Borderline tumour | |||
|---|---|---|---|---|
Cases (n=478) | Controls (n=1421) | Cases (n=190) | Controls (n=568) | |
Age at diagnosis (years) a | ||||
Median (range) | 52 (33–78) | 51 (30–77) | 49 (26–76) | 49 (23–78) |
Time between serum sampling and diagnosis (years) a | ||||
Median (range) | 7.2 (0.1–26) | 7.2 (−0.5–26) | 7.1 (0.1–23) | 7.2 (−0.5–23) |
Histology | ||||
Serous | 251 (53%) | 96 (51%) | ||
Mucinous | 28 (6%) | 86 (45%) | ||
Endometrioid | 76 (16%) | 3 (2%) | ||
Clear cell | 53 (11%) | |||
Mixed epithelial | 24 (5%) | |||
Undifferentiated | 20 (4%) | |||
Granulosa cell | 15 (3%) | |||
Other | 11 (2%) | 5 (3%) | ||
BRCA1 mutations | ||||
816delGT | 1 | 0 | 0 | 0 |
1135insA | 5 | 1 | 0 | 0 |
1675delA | 8 | 1 | 0 | 0 |
3347delAG | 5 | 0 | 0 | 0 |
Any mutation | 19 | 2 | 0 | 0 |
CA 125 | ||||
Median (range) | 14 (0–100) | 10 (0–100) | 15 (0–100) | 11 (0–100) |
No. positive (>35 U ml−1) | 71 | 79 | 35 | 45 |
