Table 1 Comparison of chemosensitivity in the MDA-MB-435S-F cell line and its paclitaxel selected variantsa

From: A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin

 

IC50 (ng ml−1)

Drug

MDA-MB- 435S-F

MDA-MB-435S- F/Taxol-10p

Fold resistance of MDA-MB-435S- F/Taxol-10p

MDA-MB-435S- F/Taxol-10p4p

Fold resistance of MDA-MB-435S- F/Taxol-10p4p

Doxorubicin

271±3

242±21

0.89

456±20**

1.68

Paclitaxel

28.3±1.52

259±3**

9.15

900±40**

31.80

Carboplatin

41 300±1500

54 300±5100*

1.31

33 000±3400

0.79

Docetaxel

3.33±0.37

12.23±0.37**

3.67

62.4±1.3**

18.73

VP-16

1844±77

2225±152

1.20

1740±17

0.94

5-Fluorouracil

7430±680

3500±170**

0.47

6830±600

0.91

Vincristine

12.9±1.3

74.6±0.5**

5.78

176±56**

13.64

  1. The IC50 values are the mean of a minimum of three repeat experiments.
  2. *P<0.05, Student's t-test.
  3. **P<0.005, Student's t-test.
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