Figure 5

Threshold utility analysis of the total sample (N=1669). The diagonal lines indicate the units of months gained in Q-TWiST for different utilities for Tox and Rel. The utility for TWiST is defined as utwist=1 (i.e. reference state). The solid line labelled 0 is the threshold above which CMF followed by Tam results in improved Q-TWiST. The area below 0 with hatch marks represents improved Q-TWiST for Tam alone. The shaded region (top left) represents utilities (ut and ur) for which the improvement in Q-TWiST is statistically significant (P⩽0.05). S=significant and NS=not significant.