Figure 6

Threshold utility analysis of the ER-negative cohort (N=382). The diagonal lines indicate the units of months gained in Q-TWiST for different utilities for Tox and Rel. The utilities for TWiST is defined as utwist=1 (i.e. reference state). All values of the utilities for Tox and Rel result in improved Q-TWiST for CMF followed by Tam compared with Tam alone. The shaded region (top left) represents utilities (ut and ur) for which the improvement in Q-TWiST is statistically significant (P⩽0.05). S=significant and NS=not significant.